The effect of Pharmacologic Treatment which reduces Plasma Glucose in the Urine Cytology of patients with Type II DM.

Abstract

Settings: Urine cytology is the most widely used noninvasive test to detect urothelial atypical changes. Though, it is limited by its low sensitivity, particularly in the detection of urothelial tumors, but it can be useful in identification of changes such as inflammatory conditions. Therefore, this study aimed at assessing the inflammatory, metaplastic and neoplastic (if any) that might results from the effect of pharmacologic treatment which reduces plasma glucose in females with diabetes mellitus (DM) type II. Materials and Methods: One hundred women with DM type II were selected for this study by simple random method regardless to age ethnicity. Full voided urine specimen was collected in sterile urine container and prepared to be stained according to Papanicolaou method. Results: Out of 100 cases, 60 (60%) were found with inflammatory cell infiltrates. These inflammatory cells were found to increase with increasing of duration of disease. Cytological evidences of bacterial infection were identified among 52 (61.2%) and 31 (72.1%) patients, of those under pharmacologic treatment and poor socioeconomic status respectively. No cytological atypia was observed. Conclusion: Inflammatory infiltrate was common amongst patients DM type II. The elevation in risk of urinary tract infections among type II diabetic women was mainly present in those under pharmacologic treatment to reduce plasma glucose levels. Further study to investigate the relation between bacterial infection and the type of inflammatory infiltrate is highly recommended.