Abstract:
Settings: Urine cytology is the most widely used noninvasive test to detect
urothelial atypical changes. Though, it is limited by its low sensitivity, particularly
in the detection of urothelial tumors, but it can be useful in identification of
changes such as inflammatory conditions. Therefore, this study aimed at
assessing the inflammatory, metaplastic and neoplastic (if any) that might results
from the effect of pharmacologic treatment which reduces plasma glucose in
females with diabetes mellitus (DM) type II. Materials and Methods: One
hundred women with DM type II were selected for this study by simple random
method regardless to age ethnicity. Full voided urine specimen was collected in
sterile urine container and prepared to be stained according to Papanicolaou
method. Results: Out of 100 cases, 60 (60%) were found with inflammatory cell
infiltrates. These inflammatory cells were found to increase with increasing of
duration of disease. Cytological evidences of bacterial infection were identified
among 52 (61.2%) and 31 (72.1%) patients, of those under pharmacologic
treatment and poor socioeconomic status respectively. No cytological atypia was
observed. Conclusion: Inflammatory infiltrate was common amongst patients
DM type II. The elevation in risk of urinary tract infections among type II diabetic
women was mainly present in those under pharmacologic treatment to reduce
plasma glucose levels. Further study to investigate the relation between bacterial
infection and the type of inflammatory infiltrate is highly recommended.
