Abstract:
Insulin resistance is the pathophysiological basis of dyslipidemia and hyperglycemia.Most
lipid abnormal
ities in type 2 diabetes can be explained by reduced action of insulin at the
tissuelevel.This cross sectional study was carried out to assess the impact of diabetes mellitus
on lipid profile of Sudanese
diabetic
patients treated with insulin and/or oral hyp
oglycemic
agentsat Kosti teaching hospital, during October, 2008
–
April, 2009.
One hundred and sixty
three diabetic patients aged between 15
-
85years were included. They were informed and
consented to participate in this study. Subjected patients were class
ified into three groups
according to their medication;group A (n=36)includes patientstreated with insulin, group B
(n=113)were patients treated withhypoglycemic agents and group C (n=14), those whom
wereusing
combination
of
both
insulin
and
oral
hypoglycem
ic
agent
as
treatment.Patientsblood samples were taken and examined for lipids profile and HbA
1C
using
spectrophotometric and chromatographic techniques, respectively. Obtained data were
analyzed using SPSS program for windows, V,20.
U
singstudent
-
't' test.
Patients results were
compared with results of one hundred persons as controls.
In this study there was an
elevatedmean
level
ofcholesterol(4.88±1.55mmol/L),triglycerides(2.2±0.66mmol/L),
LDL(3.1±
1.76
mmol/L), ApoB(1.48±
0.6g/L),
and HbA
1C
(10.4±4.5%), and red
uced mean
levels of HDL(1.15±
0.36
mmol/L)and ApoA (
1.62
±
0.1g/L)
in all groupswhen compared with
control. All patients were having HbA
1C
>9%.Mean values of
cholesterol
,
triglycerides
, LDL,
HDL, ApoB, ApoA and HbA
1C
of diabetic patients were found non
-
significant
when
compared with controls (
P
values were 0.340, 0.802, 0.489, 0.812, 0.342, 0.490 and 0.840),
respectively. The assessment of lipid profile in serum of diabetic patients treated with insulin
and/or oral hypoglycemic agents should be done to reduce the r
isk of fat gain to diabetic
patients.Glycemic control and treatment of dyslipidemia reduces the development and
progression of diabetic complications
