Abstract:
Urine cytology is the most widely used non invasive test to detect urothelial atypical changes.
Though, it is limited by its low sensitivity, particularly in the detection of urothelial tumors, but it can
be useful in identification of changes such as inflammatory conditions. Therefore, This study was
conducted at Kosti Teaching Hospital January- March 2009 and it aimed to assess the inflammatory,
metaplastic and neoplastic (if any) that might results from the effect of pharmacologic treatment-oral
hypoglycemic agents in females with diabetes mellitus (DM) type II. Material and Methods: One
hundred women with DM type II were recruited for this study by simple random method regardless of
their ages and ethnicities. Full voided urine specimen was collected in sterile urine container and
prepared to be stained according to Papanicolaou method. Results: Out of 100 cases, 60 (60%) were
found with inflammatory cell infiltrates. These inflammatory cells were found to increase with increasing the duration of the disease. Cytological evidences of bacterial infection were identified
among 52 (61.2%) and 31 patients (72.1%), of those under pharmacologic treatment and poor
socioeconomic status respectively. Cytological atypia was not found. Conclusion: Inflammatory
infiltrate was common amongst patients with DM type II. The elevation in risk of urinary tract
infections among type II diabetic women was mainly present in those who were on treatment. Further
studies to investigate the relation between bacterial infection and the type of inflammatory infiltrate are
recommended.
